Monsters, Inc. 2: The Great Discovery is the sequel to Monsters, Inc.
- John Goodman: James P. "Sulley" Sullivan (the dueteragonist and CEO of Monsters, Inc.)
- Billy Crystal: Michael "Mike" Wazowski (the main protagonist)
- Dakota Fanning: Boo (the tritagonist)
- Kelsey Grammer: DJ the Dinosaur (the Main antagonist who would kill Mike and kidnap Boo)
- Jennifer Tilly: Celia Mae (the secondary tritagonist)
- John Ratzenberger: Benjy, DJ's sidekick (the secondary antagonist)
- Frank Welker: Mike's Dog (the pet of Mike)